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Master's Culminating Experience

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Background: Around 35% of adults with osteoarthritis (OA) have knee osteoarthritis (KOA), which generally progresses over several years; however, some individuals experience accelerated KOA (AKOA), a rapid progression to end-stage disease within 48-months. Purpose: To assess baseline differences among those who develop the different types of KOA, and to determine if baseline characteristics and measures can be used to predict an individual’s KOA status (Common KOA or AKOA) 48 months later.

Methods: Cross-sectional analysis of data from the Osteoarthritis Initiative (OAI) was completed. At baseline, 4,769 participants were enrolled. Data from individuals (n = 1,561) free of radiographic KOA (Kellgren-Lawrence [KL]

Results: Age (p = 0.049), BMI (p < 0.001), and gender (p = 0.018) were significantly associated with KOA status. Older age was associated with a greater risk of AKOA (RRR = 1.46, p = 0.021), but not common KOA (RRR = 0.93, p =0.481). BMI was associated with a greater risk of both, but the magnitude of association was stronger with AKOA (RRR = 1.73, p = 0.001) compared to common KOA (RRR = 1.40, p < 0.001).

Conclusion: KOA reduces quality of life and thus is an important public health concern. Older, obese individuals are at greater risk of developing AKOA.

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Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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