Master's Culminating Experience
Background: Triclosan is an antibacterial agent that is added to personal care products to prevent bacterial growth. The FDA banned the use of triclosan in soap in 2016 due to safety concerns. Triclosan is considered an endocrine disruptor and had reported effects on the body, including changes in thyroid function.
Purpose: The purpose of this study was to assess the relationship between urinary triclosan and serum thyroxine in U.S adults. Methods: Data from the 2013-2014 National Health and Nutrition Examination Survey (NHANES) were analyzed (N =1,476). Linear regression analyses were performed to assess the relationship between log transformed triclosan and BMI, adjusting for age, race/ethnicity, gender, annual household income, and smoking status.
Results: Median urinary triclosan level was 5.9 ng/ml and the average serum thyroxine level was 8.10 ng/dl. After adjusting for covariates, triclosan exposure did not have a significant association with serum thyroxine (B= -0.005, 95% CI= -0.047, 0.037, p = .820). The results were similar when stratified by gender. Across gender, females had a higher exposure of triclosan than males with an average level of 2.08 ng/ml compared to 1.81 ng/ml. Females also had higher thyroxine (8.29 ng/dl) levels.
Conclusion: Endocrine disruptors are a public health issue and can impact the burden of chronic disease. Although this study did not show a significant between triclosan and thyroxine, it did identify factors associated with thyroxine levels. Additional research needs to be done to further assess the relationship between triclosan and thyroxine.
Clark, K. M. (2018). The Effect of Urinary Triclosan on SerumThyroxine in US Population: 2011-2012 NHANES Data.Wright State University, Dayton, Ohio.
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