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Master's Culminating Experience

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Purpose: To explore the relationship between the common pesticides, 2,4-dichlorophenol (2,4-DCP) and 2,5-dichlorophenol (2,5-DCP) with serum creatinine as a biomarker of kidney function. Methods: National Health and Nutrition Examination Survey (NHANES) 2013 to 2014 data (N = 2,063, 47% male and 53% female) was used to statistically analyze the relationship between either of two common pesticides 2,4-DCP or 2,5-DCP and serum creatinine levels. Gender stratified analysis was completed using multivariate adjusted linear regression. Variables adjusted were age, ethnicity and annual household income. Results: In both males and females exposure to 2,4-DCP did not elevate serum creatinine and regression results were not significant. For 2,5-DCP exposure, serum creatinine was not significantly elevated in males. However, in females, 2,5-DCP exposure was associated with significant decrease in serum creatinine at p = .017. Conclusion: These pesticides continue to be of human health concerns, and with varied results in both genders. Further testing is warranted.

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Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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