Master's Culminating Experience
Purpose: To explore the relationship between the common pesticides, 2,4-dichlorophenol (2,4-DCP) and 2,5-dichlorophenol (2,5-DCP) with serum creatinine as a biomarker of kidney function. Methods: National Health and Nutrition Examination Survey (NHANES) 2013 to 2014 data (N = 2,063, 47% male and 53% female) was used to statistically analyze the relationship between either of two common pesticides 2,4-DCP or 2,5-DCP and serum creatinine levels. Gender stratified analysis was completed using multivariate adjusted linear regression. Variables adjusted were age, ethnicity and annual household income. Results: In both males and females exposure to 2,4-DCP did not elevate serum creatinine and regression results were not significant. For 2,5-DCP exposure, serum creatinine was not significantly elevated in males. However, in females, 2,5-DCP exposure was associated with significant decrease in serum creatinine at p = .017. Conclusion: These pesticides continue to be of human health concerns, and with varied results in both genders. Further testing is warranted.
James, K. (2019). Dichlorophenol Exposure and Chronic Kidney Disease. Wright State University. Dayton, Ohio.
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