Master's Culminating Experience
Background/Aim: Perfluoroalkyl substances (PFASs) are chemical compounds used in consumer products and are linked with increase in cholesterol, thyroid disease, and pregnancy-induced hypertension. However, their association with lung function is not completely understood.
Methods: Cross sectional 2011-12 U.S. population data from the National Health and Nutrition Examination Survey (NHANES) was used (N=1,450, aged 12 to 79 years, 52% men). Serum concentration of four PFASs, perfluorononanoic acid (PFNA), perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), and perfluorohexane sulfonic acid (PFHxS) were assessed using mass spectrometry and were categorized into tertiles. Lung function was measured by spirometry as forced vital capacity (FVC), forced expiratory volume in one second (FEV1), and the ratio of FVC/FEV1 (%). Sex stratified adjusted linear regression analysis was used to predict lung function with PFASs tertiles.
Results: In men all four PFASs serum concentrations and lung function was higher, except FVC/FEV1 (%) which was lower than women (p
Conclusion: High PFASs exposure has a consistent significant negative impact on female lung function in unadjusted analysis and this association needs further exploration.
Heinle, B. C. (2019). The Association of Perfluoroalkyl Substance Exposure and Lung Function in the U.S. Population. Wright State University. Dayton, Ohio.
Additional FilesILE Poster HeinleB_Final.pdf (920 kB)