Repository Citation
Pak, Kaitlynne; Gunawardena, Sanuri; Torralba, Ericson; Linares, Juan; Valencia, Damian; and Dittoe, Nathaniel, "Methamphetamine Associated Cardiomyopathy and Fatal Thrombus Formation" (2021). Medical Student Research Symposium Abstracts and Posters. 2.
https://corescholar.libraries.wright.edu/msrs/2021/poster_presentations_1/2
Start Date
29-4-2021 7:15 PM
End Date
29-4-2021 7:25 PM
Document Type
Poster
Description
Stimulant abuse is a rapidly growing epidemic both in the United States, and around the world. Reports show that nearly 4.7 million Americans have tried methamphetamines at least once. It is known that methamphetamines and related compounds significantly increase cardiovascular morbidity and mortality. Substance-related chronic inflammation and tissue fibrosis can cause irreversible cardiac structural changes, leading to conditions like methamphetamine-associated dilated cardiomyopathy (MACM). Left ventricular dilation results in hemodynamic flow disturbances, which promote turbulent blood flow and stagnation. Furthermore, the sympathomimetic effects of methamphetamines also disrupt pathways in coagulation homeostasis, providing further incitement of thrombus formation. This unstable catecholamine driven pathway is thought to create myocardial ischemia via direct free radical oxidation, mitochondrial injury, and metabolic derangements. This is thought to be the cause of left ventricular systolic dysfunction with apical ballooning and hypokinesis. Here, we report a case of large left ventricular thrombus formation in the setting of methamphetamine-associated cardiomyopathy.
Abstract - Pak
Additional Files
Pak_Abstract-Methamphetamine Associated Cardiomyopathy and Fatal Thrombus Formation-ocr.pdf (321 kB)Abstract - Pak
Included in
Methamphetamine Associated Cardiomyopathy and Fatal Thrombus Formation
Stimulant abuse is a rapidly growing epidemic both in the United States, and around the world. Reports show that nearly 4.7 million Americans have tried methamphetamines at least once. It is known that methamphetamines and related compounds significantly increase cardiovascular morbidity and mortality. Substance-related chronic inflammation and tissue fibrosis can cause irreversible cardiac structural changes, leading to conditions like methamphetamine-associated dilated cardiomyopathy (MACM). Left ventricular dilation results in hemodynamic flow disturbances, which promote turbulent blood flow and stagnation. Furthermore, the sympathomimetic effects of methamphetamines also disrupt pathways in coagulation homeostasis, providing further incitement of thrombus formation. This unstable catecholamine driven pathway is thought to create myocardial ischemia via direct free radical oxidation, mitochondrial injury, and metabolic derangements. This is thought to be the cause of left ventricular systolic dysfunction with apical ballooning and hypokinesis. Here, we report a case of large left ventricular thrombus formation in the setting of methamphetamine-associated cardiomyopathy.
