The Rh_o(D) Specificity of a Polysaccharide Isolated from a Species of Pseudomonas

Authors

Nancy J. Bigley, Wright State University - Main CampusFollow
Matthew C. Dodd
Chester I. Randles
Virginia B. Geyer
Alvin G. Lazen

Document Type

Article

Publication Date

4-1963

Abstract

A polysaccharide from an unidentified species of Pseudomonas (PsP) has been shown to possess antigenic specificity similar to the Rh_o(D) antigen of human red cells. The following findings revealed this specificity: a) PsP inhibited anti-D agglutinins; b) anti-PsP rabbit sera contained both saline agglutinins and incomplete antibodies specific only for cells containing D antigen; c) D-positive cells absorbed specific agglutinins from anti-PsP sera; d) anti-D serum blocked agglutination of D cells by anti-PsP serum. Agglutination of D cells by anti-PsP rabbit serum was inhibited by N-acetylneuraminic acid (NANA) containing substances different from those previously shown to inhibit D cell agglutination by specific Rh antiserum. It was concluded that the antigenic similarity is not due to NANA but to some structure or linkage resembling it.

Repository Citation

Bigley, N. J., Dodd, M. C., Randles, C. I., Geyer, V. B., & Lazen, A. G. (1963). The Rh_o(D) Specificity of a Polysaccharide Isolated from a Species of Pseudomonas. The Journal of Immunology, 90 (4), 526-531.
https://corescholar.libraries.wright.edu/ncbp/494