Application of a Method Used to Deconstruct a Single Dose Pharmacokinetic Profile from Multiple Dose Data
Document Type
Article
Publication Date
9-2015
Abstract
With traditional non-compartmental methods, it is challenging to deconstruct plasma concentration versus time curves to assess the influence of individual doses. This study describes the application of a mathematical approach used to deconstruct a single dose curve using data derived from the second, third, fourth or nth dosing interval. Using data from a prospective clinical trial it is demonstrated that this approach reliably estimates pharmacokinetic parameters measured following two doses of zolpidem tartrate. Additionally, the study demonstrates the application of this approach using previously published data from a single- and multiple-dose pharmacokinetic study of the antibiotic gatifloxacin.
Repository Citation
Stockmann, C.,
Spigarelli, M. G.,
Healy, D. P.,
Gottschlich, M.,
Kagan, R. J.,
Balch, A. H.,
& Sherwin, C. M.
(2015). Application of a Method Used to Deconstruct a Single Dose Pharmacokinetic Profile from Multiple Dose Data. Biopharmaceutics and Drug Disposition, 36 (6), 405-409.
https://corescholar.libraries.wright.edu/pediatrics/353
DOI
10.1002/bdd.1949
