Longitudinal 1H MRS of Rat Forebrain from Infancy to Adulthood Reveals Adolescence as a Distinctive Phase of Neurometabolite Development
This study represents the first longitudinal, within-subject (1) H MRS investigation of the developing rat brain spanning infancy, adolescence and early adulthood. We obtained neurometabolite profiles from a voxel located in a central location of the forebrain, centered on the striatum, with smaller contributions for the cortex, thalamus and hypothalamus, on postnatal days 7, 35 and 60. Water-scaled metabolite signals were corrected for T1 effects and quantified using the automated processing software LCModel, yielding molal concentrations. Our findings indicate age-related concentration changes in N-acetylaspartate + N-acetylaspartylglutamate, myo-inositol, glutamate + glutamine, taurine, creatine + phosphocreatine and glycerophosphocholine + phosphocholine. Using a repeated measures design and analysis, we identified significant neurodevelopment changes across all three developmental ages and identified adolescence as a distinctive phase in normative neurometabolic brain development. Between postnatal days 35 and 60, changes were observed in the concentrations of N-acetylaspartate + N-acetylaspartylglutamate, glutamate + glutamine and glycerophosphocholine + phosphocholine. Our data replicate past studies of early neurometabolite development and, for the first time, link maturational profiles in the same subjects across infancy, adolescence and adulthood.
Morgan, J. J.,
Kleven, G. A.,
Tulbert, C. D.,
Horita, D. A.,
& Ronca, A. E.
(2013). Longitudinal 1H MRS of Rat Forebrain from Infancy to Adulthood Reveals Adolescence as a Distinctive Phase of Neurometabolite Development. NMR in Biomedicine, 26 (6), 683-691.