Sensitization of Depressive-Like Behavior Is Attenuated by Disruption of Prostaglandin Synthesis Days Following Brief Early Attachment-Figure Isolation

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108056067 (Orcid)


Isolation of guinea pig pups from the maternal attachment figure in threatening surroundings leads to a sensitization of inflammatory-mediated, depressive-like behavior and fever during later periods of isolation. A previous study found that the non-selective COX inhibitor naproxen administered before the initial period of isolation moderated depressive-like behavior and its sensitization. Here, we examined the effect of naproxen given following early isolation. Male and female guinea pig pups surgically implanted with telemetry devices to measure core temperature were isolated for 3 h on two consecutive days prior to weaning (first isolation Day 20–24). Beginning several days later, guinea pigs were injected for 4 consecutive days with either saline vehicle, or 10 or 20 mg/kg naproxen prior to a final isolation in early adolescence, i.e., 10 days after their first isolation. Across the first two isolations there was a sensitization of depressive-like behavior and fever. Both doses of naproxen attenuated levels of depressive-like behavior during the third isolation in early adolescence. Fever was unaffected. Results suggest prostaglandin mediation of the sensitization of depressive-like behavior, but not febrile responses, to subsequent periods of isolation. Findings also support the further study of anti-inflammatory treatments to mitigate lasting consequences of early-attachment disruption.


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