Alpha-Melanocyte Stimulating Hormone Reduces Putative Stress-Induced Sickness Behaviors in Isolated Guinea Pig Pups
We have proposed that passive responses observed following maternal separation in guinea pig pups represent “stress-induced sickness behaviors” mediated by proinflammatory processes. In this study, the anti-inflammatory peptide, alpha-melanocyte stimulating hormone (α-MSH) administered intracerebroventricularly, but not intraperitoneally, reduced the passive responses of crouching, eye-closing, and extensive piloerection relative to levels following administration of vehicle. These findings support our hypothesis and are as would be expected if pro-inflammatory processes act centrally to promote the passive behaviors of separated guinea pig pups.
Schiml-Webb, P. A.,
Greenlee, T. M.,
Maken, D. S.,
& Hennessy, M. B.
(2006). Alpha-Melanocyte Stimulating Hormone Reduces Putative Stress-Induced Sickness Behaviors in Isolated Guinea Pig Pups. Behavioural Brain Research, 168 (2), 326-330.