Publication Date
2012
Document Type
Thesis
Committee Members
Larry G. Arlian (Committee Chair), David Goldstein (Other), Andrew Hsu (Other), Barbara Hull (Committee Member), Courtney Sulentic (Committee Member)
Degree Name
Master of Science (MS)
Abstract
House dust mites are a group of mites that are commonly found in homes worldwide. The three most commonly found species of house dust mites in temperate environments in the United States are Dermatophagoides farinae, Dermatophagoides pteronyssinus and Euroglyphus maynei. House dust mite allergens are strongly associated with asthma, perennial rhinitis and atopic dermatitis. Whole dust mite extracts contain both allergen and non-allergen molecules that can influence cell functions in the skin, mucous membranes of the nose and eyes, and epithelial linings of the lungs. Extracts from the three different house dust mite species contain different molecules that induce different responses. The purpose of this study was to investigate how molecules in house dust mite extracts modulate IL-6, IL-8, MCP-1 and M-CSF cytokine gene expression and secretion by normal human dermal fibroblast (NHDF) cells. This study demonstrated that in some instances cytokine gene expression and secretion were induced while in other instances only stored cytokine was released by NHDF cells.
Page Count
115
Department or Program
Department of Biological Sciences
Year Degree Awarded
2012
Copyright
Copyright 2012, all rights reserved. This open access ETD is published by Wright State University and OhioLINK.
