Title

Effect of Mitochondrial Inhibitors on Type I Cells

Document Type

Conference Proceeding

Publication Date

2003

Abstract

Inhibitors of mitochondrial function have been known to be stimulants of the carotid body for many decades. Recent experiments have demonstrated that in isolated neonatal rat type I cells both hypoxia and mitochondrial uncouplers inhibit background K+ currents. This leads to membrane depolarisation and voltage gated Ca2+ entry (Buckler, 1997; Buckler and Vaughan-Jones, 1998). Since these data are consistent with a role for mitochondria in oxygen sensing, we have determined whether other mitochondrial inhibitors mimic the effects of hypoxia on the type I cells.

Comments

Presented at the 15th International Symposium on Arterial Chemoreception, Lyon, France.

DOI

10.1007/978-1-4419-9280-2_7