Effect of Mitochondrial Inhibitors on Type I Cells

Authors

Christopher N. Wyatt, Wright State University - Main CampusFollow
Keith J. Buckler

Document Type

Conference Proceeding

Publication Date

2003

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Abstract

Inhibitors of mitochondrial function have been known to be stimulants of the carotid body for many decades. Recent experiments have demonstrated that in isolated neonatal rat type I cells both hypoxia and mitochondrial uncouplers inhibit background K+ currents. This leads to membrane depolarisation and voltage gated Ca2+ entry (Buckler, 1997; Buckler and Vaughan-Jones, 1998). Since these data are consistent with a role for mitochondria in oxygen sensing, we have determined whether other mitochondrial inhibitors mimic the effects of hypoxia on the type I cells.

Comments

Presented at the 15th International Symposium on Arterial Chemoreception, Lyon, France.

Repository Citation

Wyatt, C. N., & Buckler, K. J. (2003). Effect of Mitochondrial Inhibitors on Type I Cells. Chemoreception: From Cellular Signaling to Functional Plasticity, 536, 55-58.
https://corescholar.libraries.wright.edu/ncbp/843

DOI

10.1007/978-1-4419-9280-2_7