Sublingual Drug Delivery

Authors

Tarun Goswami, Wright State University - Main CampusFollow
Bhaskara Jasti
Xiaoling Li

Document Type

Article

Publication Date

2008

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Abstract

The sublingual route is one of the early modes of administration for systemic drug delivery. This route avoids first-pass metabolism and affords quick drug entry into the systemic circulation. Attempts have been made to deliver various pharmacologically active agents, such as cardiovascular drugs, analgesics, and peptides, across the sublingual mucosa. In this review, the anatomical structure, blood supply, biochemical composition, transport pathways, permeation enhancement strategies, in vitro / in vivo models, and clinical investigations for the sublingual route of drug delivery is discussed

Repository Citation

Goswami, T., Jasti, B., & Li, X. (2008). Sublingual Drug Delivery. Critical Reviews in Therapeutic Drug Carrier Systems, 25 (5), 449-484.
https://corescholar.libraries.wright.edu/bie/261

DOI

10.1615/CritRevTherDrugCarrierSyst.v25.i5.20