Brain Osmolyte Content and Blood-Brain Barrier Water Permeability Surface Area Product in Osmotic Edema
Document Type
Article
Publication Date
1994
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Abstract
Brain edema was induced in adult rats by intraperitoneal injection of distilled water equivalent to 15% of the animal’ s body weight. Mean ± SEM serum osmolality fell from 291 ± 3 mOsm to 253 ± 4 mOsm during the next hour while cerebral gray matter water content increased from 79.5 ± 0.2% to 80.9 ± 0.2%. Gray matter content of sodium, potassium, taurine, glycine, glutamine, and glutamate were unchanged. However, the blood-brain barrier permeability/surface area product for water decreased by 40%. This alteration in water permeability may represent a response to limit water influx during the first hour of hypoosmotic brain edema.
Repository Citation
Olson, J. E.,
Evers, J. A.,
& Banks, M.
(1994). Brain Osmolyte Content and Blood-Brain Barrier Water Permeability Surface Area Product in Osmotic Edema. Acta neurochirurgica. Supplementum, 60, 571-573.
https://corescholar.libraries.wright.edu/emergency_medicine/254
DOI
10.1007/978-3-7091-9334-1_158
