Publication Date


Document Type


Committee Members

Ji Chen Bihl (Committee Member), Yanfeng Chen (Committee Member), Adrian Corbett (Advisor)

Degree Name

Master of Science (MS)


In this study, we hypothesize that a pharmacological drug treatment comprised of Fluoxetine, Simvastatin and Ascorbic acid together with physical rehabilitation would reduce infarct sizes. Over the period of 60 days after stroke-induction, 13 of the 23 rats were administered the drugs beginning 20-26 hours after stroke-induction and the rest were assigned to the control group. Physical rehabilitation exercises were initiated from poststroke day 8 and continued for 23 alternate days. The rats were tested for functional recovery using Montoya staircase apparatus and were euthanized after post-stroke day 60. The brains sections were analyzed using Nissl stain for infarct volume analysis. Due to the excess amount physical rehabilitation exercise in comparison to the previous studies conducted in our laboratory, the rats suffered large amount of stress. Stress antagonizing neurogenesis is believed to be the reason for lack of motor functional recovery and lack of any reduction in infarct sizes.

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Department or Program

Department of Pharmacology and Toxicology

Year Degree Awarded


Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.