Adrian Corbett (Committee Member), Lynn Hartzler (Advisor), Barbara Hull (Committee Member)
Master of Science (MS)
Stroke is one of the leading causes of deaths as the risk factors, both controllable and uncontrollable, are many. We first concentrated on a stress-free way to deliver the drugs. Our preference was to have the animals ingest the drugs, which led us to a reliable method for orally administering medication to the animal models. Using three different drug combinations, we tested the effects on neurogenesis without stroke. We found the drug combination of Fluoxetine/Statin/Ascorbic acid increases neurogenesis 19 fold when compared with control. Lastly, we looked at the gene changes in the cortex of the animal models that had been administered our drug treatment. We noted that the fluoxetine treatment group was involved in up-regulated genes showing genetic themes related to molecular functions for channel activity and that the fluoxetine/statin combination treatment group was associated with clotting activity as well as an immune response.
Department or Program
Department of Biological Sciences
Year Degree Awarded
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