Publication Date


Document Type


Committee Members

Adrian Corbett (Committee Co-Chair), Larry Ream (Committee Member), Christopher Wyatt (Committee Co-Chair)

Degree Name

Master of Science (MS)


Some acid sensing areas in the brain control the expression of breathing and anxiety/fear including the locus coeruleus (LC) (Redmond & Huang, 1979) and the nucleus tractus solitarius (NTS). It has been found that knocking out T-cell death-associated gene 8 (TDAG8), a chemosensor, attenuates CO2 induced fear phenotypes in mice. However their hypercapnic ventilatory response (HCVR) has not yet been looked at. Also, BK channels are large-conductance, calcium-activated potassium channels that are activated by increases in concentration of intracellular calcium ions. It has been found that BK KO rats have an increase in their HCVR (Patrone et al., 2014) however their CO2 induced anxiety/fear has not been looked at yet. In this thesis, we found that the BK channel is involved in the HCVR in mice and that the CO2 induced anxiety/fear pathway and the HCVR pathway are separate pathways in the BK and the TDAG8 mice.

Page Count


Department or Program

Department of Neuroscience, Cell Biology, and Physiology

Year Degree Awarded