Adrian Corbett (Advisor), Kathrin Engisch (Committee Member), Debra Mayes (Committee Member)
Master of Science (MS)
We tested the effect of the fluoxetine enantiomers (S-fluoxetine and R-fluoxetine) versus Prozac (50:50 ratio of R- and S- fluoxetine enantiomers) and/or control on blood brain barrier (BBB) permeability in different brain regions in both male and female rats. The rats consumed orally the drug (5 mg/kg) or vehicle for a total of three days, then were injected with sterile Evans blue dye ip, at least 12 hours before euthanasia.. We see significant regional brain differences in BBB permeability (hippocampus has tighter BBB), significant differences based on the age of the animals (young rats show enhanced permeability in lower brain region), and significant differences based on the sex of animals interacting with specific regional differences in BBB permeability (female rats have enhanced permeability in cerebellum). We also see some effect of the fluoxetine enantiomers, with S-fluoxetine enhancing permeability, and R fluoxetine reducing permeability.
Department or Program
Department of Neuroscience, Cell Biology, and Physiology
Year Degree Awarded
Copyright 2017, all rights reserved. My ETD will be available under the "Fair Use" terms of copyright law.