Publication Date


Document Type


Committee Members

Larry G. Arlian (Committee Chair), David Goldstein (Other), Andrew Hsu (Other), Barbara Hull (Committee Member), Courtney Sulentic (Committee Member)

Degree Name

Master of Science (MS)


House dust mites are a group of mites that are commonly found in homes worldwide. The three most commonly found species of house dust mites in temperate environments in the United States are Dermatophagoides farinae, Dermatophagoides pteronyssinus and Euroglyphus maynei. House dust mite allergens are strongly associated with asthma, perennial rhinitis and atopic dermatitis. Whole dust mite extracts contain both allergen and non-allergen molecules that can influence cell functions in the skin, mucous membranes of the nose and eyes, and epithelial linings of the lungs. Extracts from the three different house dust mite species contain different molecules that induce different responses. The purpose of this study was to investigate how molecules in house dust mite extracts modulate IL-6, IL-8, MCP-1 and M-CSF cytokine gene expression and secretion by normal human dermal fibroblast (NHDF) cells. This study demonstrated that in some instances cytokine gene expression and secretion were induced while in other instances only stored cytokine was released by NHDF cells.

Page Count


Department or Program

Department of Biological Sciences

Year Degree Awarded


Included in

Biology Commons