Publication Date
2006
Document Type
Thesis
Committee Members
Robert Casillas (Advisor)
Degree Name
Master of Science (MS)
Abstract
The present study was conducted to determine the half-life, assess the toxicity, and passive protection efficacy of purified immunoglobulin G (IgG) from Anthrax Vaccine Adsorbed (AVA) vaccinated human donors. Half-life determinations were calculated from the reportable values obtained using the anti-PA ELISA assay and the Centers for Disease Control's (CDC) "ELISA for Windows" software. For toxicity evaluations animals were observed clinical for one hour post administration and for 14-days post-treatment. The protection efficacy was determined based upon the mortality results from a lethal Bacillus anthracis aerosol challenge. While no protection was achieved in this delayed exposure scenario, the study yielded valuable kinetics data for use in future research.
Page Count
75
Department or Program
Department of Pharmacology and Toxicology
Year Degree Awarded
2006
Copyright
Copyright 2006, all rights reserved. This open access ETD is published by Wright State University and OhioLINK.
