Publication Date


Document Type


Committee Members

Nancy Bigley (Advisor), Barbara Hull (Committee Member), Courtney Sulentic (Committee Member)

Degree Name

Master of Science (MS)


Mycobacterium tuberculosis is one of the world's most infectious diseases. Approximately 2 million people die each year from Mycobacterium tuberculosis infection and one-third of the world's population remains infected. For decades research has focused on uncovering the tactics used by Mycobacterium tuberculosis to evade host immune responses and defense mechanisms used to fight tuberculosis infection. The following review focuses on the host defense mechanisms used to combat Mycobacterium tuberculosis with an emphasis placed on the roles that Toll-like receptors (TLRs), T cells (gamma delta, CD4, CD8), and macrophages play in mounting the innate and adaptive immune responses necessary to eradicate this disease. The challenges of designing an effective vaccine to fight Mycobacterium tuberculosis infection and the two first-line anti-tuberculosis inhalant drugs, Isoniazid (H) and Rifampicin (R) are also discussed.

Page Count


Department or Program

Microbiology and Immunology

Year Degree Awarded