Publication Date


Document Type


Committee Members

Michael Hennessy (Advisor), John Pearson (Committee Member), Patricia Schiml-webb (Committee Member)

Degree Name

Master of Science (MS)


The current study examined the behavioral sensitization of guinea pig pups in response to consecutive days of maternal separation. In the first experiment, guinea pigs that received centrally administered artificial cerebrospinal fluid or IL-10 exhibited sensitization of passive behaviors from Day 1 to Day 2. IL-10 decreased the levels of passive behaviors on Day 1, as well as the increase on Day 2. The second experiment used unoperated pups, which also showed sensitization of the passive response from Day 1 to Day 2, though the effect appeared reduced relative to control pups of Experiment 1. Collectively, this investigation confirms previous evidence that passive behaviors are due in part to pro-inflammatory cytokines. It also provides evidence that the increase in passive measures from the first separation to the second may be caused by a sensitization of pro-inflammatory mechanisms.

Page Count


Department or Program

Department of Neuroscience, Cell Biology & Physiology

Year Degree Awarded


Included in

Anatomy Commons