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We share a widely-held vision that tomorrow's health care will be delivered by a distributed team using a knowledge based process that is focused on prevention and wellness. Caregivers will be able to treat and monitor patients where and when needed, capturing data as a natural byproduct of care delivery. Clinical teams with a wide range of skills and expertise will deliver consistent, quality care based on timely, situation-specific knowledge and guidance derived from outcomes evidence. That same knowledge will support advances in healthcare research and education. Home care and remote medicine will increase, reducing the need for high-cost hospitalization. The health care community will realize virtual integration through knowledge tools that deliver appropriate knowledge to care providers at the right time.