Electrophysiologic and Hemodynamic Effects of Bethanidine Sulfate on the Immature Mammalian Heart

Authors

A. Fournier
M. L. Young
Adrienne Stolfi, Wright State UniversityFollow
Henry Gelband
Arthur S. Pickoff, Wright State UniversityFollow

Document Type

Article

Publication Date

1-1-1988

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Abstract

The cumulative electrophysiologic and hemodynamic effects of bethanidine sulfate (2.5, 5, 10 and 15 mg/kg i.v.) were studied in 9 canine neonates and 7 adult dogs. Increased heart rate, blood pressure and enhanced atrioventricular nodal function, observed in both groups, and decreased ventricular refractory periods and inducibility of ventricular arrhythmias seen in the adult, are probably related to a bethanidine-mediated release of catecholamines. However, in spite of the catecholamines release, bethanidine sulfate results in a significant prolongation of atrial refractoriness, this effect being quantitatively more important in the neonate than in the adult.

Repository Citation

Fournier, A., Young, M., Stolfi, A., Gelband, H., & Pickoff, A. (1988). Electrophysiologic and Hemodynamic Effects of Bethanidine Sulfate on the Immature Mammalian Heart. Developmental Pharmacology and Therapeutics, 11 (5), 288-296.
https://corescholar.libraries.wright.edu/med_education/164

DOI

10.1159/000457704