Propagation and Control of T Cell Responses by Heparan Sulfate-Bound IL-2
IL-2, a cytokine produced by T cells, is a key regulator of immune responses and T cell homeostasis. Controlling the availability of IL-2 is consequently of significant import to the immune system. Like other cytokines, IL-2 is thought to function as a soluble agonist, transiently present when secreted in response to appropriate stimuli. In this study, we show that the most salient properties of IL-2, propagation and control of T cell responses, are mediated in vivo by bound and not free cytokine and specifically by heparan sulfate-bound IL-2. These findings necessitate a new look at how IL-2 regulates immune responses and support the notion that the microenvironment plays a determining role in modulating the character of immune responses.
Wrenshall, L. E.,
Platt, J. L.,
Stevens, E. T.,
Wight, T. N.,
& Miller, J. D.
(2003). Propagation and Control of T Cell Responses by Heparan Sulfate-Bound IL-2. The Journal of Immunology, 170 (11), 5470-5474.