Document Type
Article
Publication Date
2-14-2007
Abstract
Despite advances and options available in gene therapy for HIV-1 infection, its application in the clinical setting has been challenging. Although published data from HIV-1 clinical trials show safety and proof of principle for gene therapy, positive clinical outcomes for infected patients have yet to be demonstrated. The cause for this slow progress may arise from the fact that HIV is a complex multi-organ system infection. There is uncertainty regarding the types of cells to target by gene therapy and there are issues regarding insufficient transduction of cells and long-term expression. This paper discusses state-of-the-art molecular approaches against HIV-1 and the application of these treatments in current and ongoing clinical trials.
Repository Citation
Marathe, J. G.,
& Wooley, D. P.
(2007). Is Gene Therapy a Good Therapeutic Approach for HIV-Positive Patients?. Genetic Vaccines and Therapy, 5 (5), 1-9.
https://corescholar.libraries.wright.edu/ncbp/186
DOI
10.1186/1479-0556-5-5
Included in
Medical Cell Biology Commons, Medical Neurobiology Commons, Medical Physiology Commons, Neurosciences Commons, Physiological Processes Commons
Comments
© 2007 Marathe and Wooley; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.