Key Roles for AMP-Activated Protein Kinase in the Function of the Carotid Body?
Document Type
Conference Proceeding
Publication Date
2008
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Abstract
The carotid bodies play a critical role in initiating compensatory ventilatory responses to hypoxia. However, the complete mechanism by which hypoxia excites the oxygen-sensing carotid body type 1 cells has not been fully defined. We have previously proposed that the enzyme adenosine monophosphateactivated protein kinase (AMPK) may couple hypoxic inhibition of mitochondrial oxidative phosphorylation to carotid body type I cell excitation (Evans, Mustard, Wyatt, Peers, Dipp, Kumar, Kinnear and Hardie 2005). Here we discuss evidence that AMPK is a key requirement for hypoxic chemotransduction by the carotid body. In addition, we postulate upon a role for AMPK in the plasticity observed in the carotid body during both chronic and chronic intermittent hypoxia.
Repository Citation
Wyatt, C. N.,
Pearson, S. A.,
Kumar, P.,
Peers, C.,
Hardie, D. G.,
& Evans, A. M.
(2008). Key Roles for AMP-Activated Protein Kinase in the Function of the Carotid Body?. Advances in Experimental Medicine and Biology: Integration in Respiratory Control, 605 (2), 63-68.
https://corescholar.libraries.wright.edu/ncbp/200
DOI
10.1007/978-0-387-73693-8_11
Comments
Presented at the 10th Oxford Conference on Modeling and Control of Breathing, Lake Louise, Alberta, Canada.