Specific Inhibition of RH₀(D) Antibody by Sialic Acids

Authors

Matthew C. Dodd
Nancy J. Bigley, Wright State University - Main CampusFollow
Virginia B. Geyer

Document Type

Article

Publication Date

11-11-1960

Abstract

Agglutination of Rh_O(D) erythrocytes by specific antiserum was inhibited by crude and crystalline N-acetylneuraminic acid, less inhibited by its glycoyl derivative, and weakly inhibited by its degradation product, N-acetyl-mannosamine, and by D-mannose. A brain ganglioside containing neuraminic acid and a Pseudomonas polysaccharide were even more inhibitory. Inhibition was specific for anti-D sera.

Repository Citation

Dodd, M. C., Bigley, N. J., & Geyer, V. B. (1960). Specific Inhibition of RH₀(D) Antibody by Sialic Acids. Science, 132 (3437), 1398-1399.
https://corescholar.libraries.wright.edu/ncbp/487

DOI

10.1126/science.132.3437.1398