A Computer Model of Mammalian Central CO₂ Chemoreception

Authors

Mykyta M. Chernov
Robert W. Putnam, Wright State University - Main CampusFollow
James C. Leiter

Document Type

Book Chapter

Publication Date

2008

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Abstract

We developed a single compartment model of a mammalian CO₂ sensitive neuron and tested the hypothesis that pH-dependent inhibition of multiple potassium channels contributes to CO₂sensitivity. pH-dependent inhibition of potassium channels by either intracellular or extracellular pH was sufficient to alter neuronal activity, but changes in neither intracellular nor extracellular pH are required to elicit a neuronal response to hypercapnic stimulation.

Repository Citation

Chernov, M. M., Putnam, R. W., & Leiter, J. C. (2008). A Computer Model of Mammalian Central CO₂ Chemoreception. Integration in Respiratory Control: From Genes to Systems, 605, 301-305.
https://corescholar.libraries.wright.edu/ncbp/704

DOI

10.1007/978-0-387-73693-8_52