Control of HCO₃-Dependent Exchangers by Cyclic Nucleotides in Vascular Smooth Muscle Cells

Authors

Robert W. Putnam, Wright State University - Main CampusFollow
Phyllis B. Douglas
Dianne E. Dewey

Document Type

Book Chapter

Publication Date

1991

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Abstract

A variety of membrane transport systems responsible for the regulation of intracellular pH (pH_i) have been identified in smooth muscle (Aickin, 1986; Aalkjaer and Cragoe, 1988; Wray, 1988; Kikeri et al., 1990) and smooth muscle-like cells (Boyarsky et al.,1988a,b; Putnam,1990). These include the ubiquitous Na/H exchanger and at least two HC0₃-dependent transport systems (Fig. 1): i) a putative alkalinizing (Na + HCO₃)/C1 exchanger (although the role of Cl in this exchanger is still at issue) (Aickin and Brading, 1984; Aalkjaer and Mulvany, 1988); and ii) an acidifying Cl/HCO₃ exchanger. While these exchangers are important for determining steady state pH_i (Aalkjaer and Cragoe, 1988; Boyarsky et al., 1988a; Wray, 1988; Kikeri et al., 1990; Putnam and Grubbs, 1990), defending pH_iagainst acid/base disturbances (Aalkjaer and Cragoe, 1988; Boyarsky et al., 1988b; Putnam, 1990) and mediating cellular responses to external signals (Berk et al., 1987; Ganz et al., 1989), only the Na/H exchanger has been extensively studied in regard to the factors which regulate its activity. In fact, the regulation of the HCO₃-dependent transport systems is poorly studied in any cell.

Repository Citation

Putnam, R. W., Douglas, P. B., & Dewey, D. E. (1991). Control of HCO₃-Dependent Exchangers by Cyclic Nucleotides in Vascular Smooth Muscle Cells. Regulation of Smooth Muscle Contraction, 304, 461-472.
https://corescholar.libraries.wright.edu/ncbp/744

DOI

10.1007/978-1-4684-6003-2_39