Does AMP-Activated Protein Kinase Couple Inhibition of Mitochondrial Oxidative Phosphorylation by Hypoxia to Pulmonary Artery Constriction?

Authors

A. Mark Evans
Kirsteen J. W. Mustard
Christopher N. Wyatt, Wright State University - Main CampusFollow
Michelle Dipp
Nicholas P. Kinnear
D. Grahame Hardie

Document Type

Conference Proceeding

Publication Date

2006

Find in a Library

Catalog Record

Abstract

Pulmonary arteries constricts in response to hypoxia and thereby aid ventilation-perfusion matching in the lung. Although O₂-sensitive mechanisms independent of mitochondria may also play a role, it is generally accepted that relatively mild hypoxia inhibits mitochondrial oxidative phosphorylation and that this underpins, at least in part, cell activation. Despite this consensus, the mechanism by which inhibition of mitochondrial oxidative phosphorylation couples to Ca²⁺-dependent vasoconstriction has remained elusive. To date, the field has focussed on the role of the cellular energy status (ATP), reduced redox couples and reactive oxygen species respectively, but investigation of these hypotheses has delivered conflicting data and failed to unite the field.

Comments

Presented at the 16th Meeting of the International Society for Arterial Chemoreception (ISAC), Sendai, Japan.

Repository Citation

Evans, A. M., Mustard, K. J., Wyatt, C. N., Dipp, M., Kinnear, N. P., & Hardie, D. G. (2006). Does AMP-Activated Protein Kinase Couple Inhibition of Mitochondrial Oxidative Phosphorylation by Hypoxia to Pulmonary Artery Constriction?. Arterial Chemoreceptors, 580, 147-154.
https://corescholar.libraries.wright.edu/ncbp/840

DOI

10.1007/0-387-31311-7_22