Molecular Changes Associated with Replication of Simian Immunodeficiency Virus in Human Cells

Authors

Toshiaki Kodama
Dawn P. Wooley, Wright State University - Main CampusFollow
Harry W. Kestler III
Muthiah D. Daniel
Ronald C. Desrosiers

Document Type

Article

Publication Date

1990

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Abstract

The SIVmac239 infectious clone does not have a premature stop codon in its transmembrane protein (TMP) region and it produces full-length (41 kilodalton, kDa) TMP in macaque peripheral blood lymphocytes (PBL) in vitro and in vivo. However, viruses with truncated forms of TMP (28kDa) are selected during propagation in human cell types; truncated forms arise from point mutations, CAG (glutamine) to TAG (stop), in the viral genome. These results document molecular changes associated with adaptation of SIVmac for growth in human cells.

Repository Citation

Kodama, T., Wooley, D. P., Kestler, H. W., Daniel, M. D., & Desrosiers, R. C. (1990). Molecular Changes Associated with Replication of Simian Immunodeficiency Virus in Human Cells. Journal of Medical Primatology, 19 (3-4), 431-437.
https://corescholar.libraries.wright.edu/ncbp/961