Effects of Polycystic Ovarian Syndrome on In Vitro Fertilization-embryo Transfer Outcomes are Influenced by Body Mass Index

Document Type

Article

Publication Date

12-2008

Abstract

Objective

To determine whether polycystic ovary syndrome (PCOS) adversely impacts IVF–embryo transfer outcomes in obese compared to lean patients.

Design

Retrospective chart review.

Setting

University-affiliated infertility program.

Patient(s)

Lean non-PCOS (n = 52), lean PCOS (n = 6), obese non-PCOS (n = 18), and obese PCOS (n = 10).

Intervention(s)

Ninety-four fresh nondonor IVF–embryo transfer cycles analyzed.

Main Outcome Measure(s)

Cycle characteristics, clinical pregnancy (PR) and live birth rates.

Result(s)

Lean PCOS had more dominant follicles (12.2 ± 6.0 vs. 7.7 ± 3.6), retrieved oocytes (22.2 ± 9.2 vs. 12.6 ± 5.8), and frozen embryos (5 ± 4.6 vs. 1.4 ± 2.6) than lean non-PCOS. Lean PCOS also used fewer gonadotropin ampules (18.8 ± 6.0 vs. 29.2 ± 14.2), but had more retrieved oocytes (22.2 ± 9.2 vs.14.3 ± 4.9) than obese PCOS. Obese non-PCOS had better-grade embryos (2.1 ± 0.8 vs. 2.7 ± 0.8) and fewer embryos transferred (2.4 ± 0.6 vs. 2.9 ± 0.6) than obese PCOS, but more embryos frozen than lean non-PCOS (3.2 ± 3.2 vs. 1.4 ± 2.6). Implantation rates trended downward in obese patients with PCOS, but no other differences were observed.

Conclusion(s)

Patients with PCOS with a body mass index (BMI) in the lean rather than the obese range have more favorable assisted reproductive technology (ART) cycle characteristics but show no clinical outcome differences.

DOI

10.1016/j.fertnstert.2007.10.077

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