Challenges Associated with Route of Administration in Neonatal Drug Delivery
Document Type
Article
Publication Date
2-2016
Abstract
The administration of drugs to neonates poses significant challenges. The aim of this review was to provide insight into some of these challenges and resolutions that may be encountered with several of the most commonly used routes of administration and dosage forms in neonatal care, including oral, parenteral, transdermal, intrapulmonary, and rectal. Important considerations include fluctuations in stomach pH hours to years after birth, the logistics of setting up an intravenous infusion, the need for reduced particle size for aerosol delivery to the developing neonatal lung, and variation in perirectal venous drainage. Additionally, some of the recently developed technologies for use in neonatal care are described. While the understanding of neonatal drug delivery has advanced over the past several decades, there is still a deficiency of technologies and formulations developed specifically for this population.
Repository Citation
Linakis, M. W.,
Roberts, J. K.,
Lala, A. C.,
Spigarelli, M. G.,
Medlicott, N. J.,
Reith, D.,
Ward, R.,
& Sherwin, C. M.
(2016). Challenges Associated with Route of Administration in Neonatal Drug Delivery. Clinical Pharmacokinetics, 55 (2), 185-196.
https://corescholar.libraries.wright.edu/pediatrics/226
DOI
10.1007/s40262-015-0313-z
