Pharmacokinetic Modeling of Therapies for Systemic Lupus Erythematosus

Authors

Xiaoyan Yang
Catherine M.T. Sherwin, Wright State UniversityFollow
Tian Yu
Venkata Yellepeddi
Hermine I. Brunner
Alexander A. Vinks

Document Type

Article

Publication Date

2015

Abstract

With the increasing use of different types of therapies in treating autoimmune diseases such as systemic lupus erythematosus (SLE), there is a need to utilize pharmacokinetic (PK) strategies to optimize the clinical outcome of these treatments. Various PK analysis approaches, including population PK modeling and physiologically based PK modeling, have been used to evaluate drug PK characteristics and population variability or to predict drug PK profiles in a mechanistic manner. This review outlines the PK modeling of major SLE therapies including immunosuppressants (methotrexate, azathioprine, mycophenolate and cyclophosphamide, among others) and immunomodulators (intravenous immunoglobulin). It summarizes the population PK modeling, physiologically based PK modeling and model-based individualized dosing strategies to improve the therapeutic outcomes in SLE patients.

Comments

Author Manuscript

Repository Citation

Yang, X., Sherwin, C. M., Yu, T., Yellepeddi, V., Brunner, H. I., & Vinks, A. A. (2015). Pharmacokinetic Modeling of Therapies for Systemic Lupus Erythematosus. Expert Review of Clinical Pharmacology, 8 (5), 587-603.
https://corescholar.libraries.wright.edu/pediatrics/255

DOI

10.1586/17512433.2015.1059751