Broadband 180 Degree Universal Rotation Pulses for NMR Spectroscopy Designed by Optimal Control

Authors

Thomas E. Skinner, Wright State University - Main CampusFollow
Naum I. Gershenzon, Wright State University - Main CampusFollow
Manoj Nimbalkar
Wolfgang Bermel
Burkhard Luy
Steffen J. Glaser

Document Type

Article

Publication Date

2012

Abstract

Broadband inversion pulses that rotate all magnetization components 180 degrees about a given fixed axis are necessary for refocusing and mixing in high-resolution NMR spectroscopy. The relative merits of various methodologies for generating pulses suitable for broadband refocusing are considered. The de novo design of 180 degree universal rotation pulses using optimal control can provide improved performance compared to schemes which construct refocusing pulses as composites of existing pulses. The advantages of broadband universal rotation by optimized pulses (BURBOP) are most evident for pulse design that includes tolerance to RF inhomogeneity or miscalibration. We present new modifications of the optimal control algorithm that incorporate symmetry principles and relax conservative limits on peak RF pulse amplitude for short time periods that pose no threat to the probe. We apply them to generate a set of pulses suitable for widespread use in Carbon-13 spectroscopy on the majority of available probes.

Comments

Downloadable article is the authors' preprint

Repository Citation

Skinner, T. E., Gershenzon, N. I., Nimbalkar, M., Bermel, W., Luy, B., & Glaser, S. J. (2012). Broadband 180 Degree Universal Rotation Pulses for NMR Spectroscopy Designed by Optimal Control. Journal of Magnetic Resonance, 216, 78-87.
https://corescholar.libraries.wright.edu/physics/1043

DOI

10.1016/j.jmr.2012.01.005