Glucocorticoids Affect Gonadotropin-Releasing Hormone Immunoreactivity in Musk Shrew Brain

Document Type

Article

Publication Date

8-2001

Abstract

Multiple interactions between the hypothalamic–pituitary–adrenal and the hypothalamic–pituitary–gonadal systems exist. In this study, we asked if glucocorticoid administration affected gonadotropin-releasing hormone (GnRH) immunoreactivity. We found that musk shrews treated with dexamethasone (DEX), a synthetic glucocorticoid, had more GnRH-immunoreactive (ir) cells in the forebrain than did cortisol- or control-treated animals. The effects of DEX were noted rapidly, within 15 min, after administration. These effects were observed in the forebrain as a whole and also in specific subpopulations of GnRH-ir cells located in the medial septum/diagonal band and the hypothalamus.

DOI

10.1006/gcen.2001.7663

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