Glucocorticoids Affect Gonadotropin-Releasing Hormone Immunoreactivity in Musk Shrew Brain
Multiple interactions between the hypothalamic–pituitary–adrenal and the hypothalamic–pituitary–gonadal systems exist. In this study, we asked if glucocorticoid administration affected gonadotropin-releasing hormone (GnRH) immunoreactivity. We found that musk shrews treated with dexamethasone (DEX), a synthetic glucocorticoid, had more GnRH-immunoreactive (ir) cells in the forebrain than did cortisol- or control-treated animals. The effects of DEX were noted rapidly, within 15 min, after administration. These effects were observed in the forebrain as a whole and also in specific subpopulations of GnRH-ir cells located in the medial septum/diagonal band and the hypothalamus.
Schiml-Webb, P. A.,
Temple, J. L.,
& Rissman, E. F.
(2001). Glucocorticoids Affect Gonadotropin-Releasing Hormone Immunoreactivity in Musk Shrew Brain. General and Comparative Endocrinology, 123 (3), 163-169.