Disorders in Molecular Assemblies for Na Transport in Essential Hypertension
Document Type
Article
Publication Date
1983
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Abstract
This chapter discusses disorders in molecular assemblies for Na transport in essential hypertension. Three different transport systems translocate Na in human red cells: the phloretin sensitive Na-Na exchange, the furosemide-sensitive Na-K cotransport, and the ouabain-sensitive Na pump. The three systems may have increasing levels of complexity in their molecular assemblies to function as Na translocators. In the Na/K ATP-dependent pump, the coupling of Na transport to ATP hydrolysis may require the assembly of another subunit(s) to catalyze the chemical reactions. Several properties of Na counter transport and cotransport permit their operational characterization as two different Na transport proteins. The systems differ in their affinity for Na and Li as well as in their sensitivity to several inhibitors, to changes in cell volume, and to replacement of chloride by nitrate. Based on these experimental findings, the chapter mentions that countertransport and cotransport are two different Na transport proteins. Na countertransport and Na-K cotransport can be simultaneously or independently altered in patients with essential hypertension and in members of their families.
Repository Citation
Canessa, M.,
Adragna, N. C.,
Bize, I.,
Solomon, H.,
& Tosteson, D. C.
(1983). Disorders in Molecular Assemblies for Na Transport in Essential Hypertension. Current Topics in Membranes and Transport, 19 (C), 951-957.
https://corescholar.libraries.wright.edu/ptox/266
DOI
10.1016/S0070-2161(08)60657-7
