Publication Date
2015
Document Type
Thesis
Committee Members
David Cool (Committee Member), Saber Hussain (Advisor), Courtney Sulentic (Committee Member)
Degree Name
Master of Science (MS)
Abstract
The Present study was designed to examine the role of agglomeration, density and the resulting fractal dimension of nanomaterials in cell culture media. Studies were completed on the kinetics and the process of agglomeration, as well as how to calculate fractal dimensions. The correlation of such complex agglomeration patterns of nanomaterials in culture media, their translocation into cells, and toxic effects were observed. Our results showed that smaller primary particles agglomerated at an accelerated rate when compared to the larger primary particles. They also demonstrated increased cellular uptake, but exhibited lower fractal dimensions. The larger primary particle agglomerates displayed obvious morphology alterations. This could be a result of greater density and sedimentation, which would disrupt cellular structure. These results reveal the biological effects of agglomerates, and how various fractal dimensions may alter cellular interactions with nanoparticles.
Page Count
101
Department or Program
Department of Pharmacology and Toxicology
Year Degree Awarded
2015
Copyright
Copyright 2015, some rights reserved. My ETD may be copied and distributed only for non-commercial purposes and may not be modified. All use must give me credit as the original author.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
