David Cool (Committee Member), Saber Hussain (Advisor), Courtney Sulentic (Committee Member)
Master of Science (MS)
The Present study was designed to examine the role of agglomeration, density and the resulting fractal dimension of nanomaterials in cell culture media. Studies were completed on the kinetics and the process of agglomeration, as well as how to calculate fractal dimensions. The correlation of such complex agglomeration patterns of nanomaterials in culture media, their translocation into cells, and toxic effects were observed. Our results showed that smaller primary particles agglomerated at an accelerated rate when compared to the larger primary particles. They also demonstrated increased cellular uptake, but exhibited lower fractal dimensions. The larger primary particle agglomerates displayed obvious morphology alterations. This could be a result of greater density and sedimentation, which would disrupt cellular structure. These results reveal the biological effects of agglomerates, and how various fractal dimensions may alter cellular interactions with nanoparticles.
Department or Program
Department of Pharmacology and Toxicology
Year Degree Awarded
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