Publication Date
2014
Document Type
Thesis
Committee Members
Eric Fossum (Committee Member), David Grossie (Other), Daniel Ketcha (Advisor), Kenneth Turnbull (Committee Member)
Degree Name
Master of Science (MS)
Abstract
Indolinones of the type known as Arylidene oxindoles have been demonstrated to possess a broad range of activity ranging from proten kinase inhibtors, cell-death inhibitors and tau protein binding agents. Small libraries of such molecules were designed and synthesized herein in modifications involving variously substituted halogen derivatives, N-alkylation of the indolinone nitrogen, and finally a new class of molecules, namely arylidene oxindoles possessing extended conjugation. The biological activities of such molecules were examined and the results disclosed herein.
Page Count
92
Department or Program
Department of Chemistry
Year Degree Awarded
2014
Copyright
Copyright 2014, all rights reserved. My ETD will be available under the "Fair Use" terms of copyright law. This may be required by third-party publishers you work with to publish your paper commercially.
