Publication Date
2020
Document Type
Thesis
Committee Members
Philippe Sucosky, Ph.D. (Advisor);Zifeng Yang, Ph.D. (Committee Member); George P. Huang, Ph.D. (Committee Member)
Degree Name
Master of Science in Renewable and Clean Energy Engineering (MSRCE)
Abstract
Calcific aortic valve disease (CAVD), the most common valvular heart disorder, is associated with complications such as stroke, heart attack, aortic aneurysm, left ventricular hypertrophy, and ultimately death. While hypertension has been identified as a major risk factor for CAVD, the mechanisms by which it may promote calcification are still unknown. Given the sensitivity of valvular tissue to mechanical stress alterations, the hemodynamic abnormalities linked to hypertension may play a role in the development of CAVD. Further, the effects of hypertension on the left ventricular functionality and coronary flow resistance remain largely uninvestigated. Hence, the objectives of this thesis were 1.) to quantify computationally AV hemodynamics and regional leaflet mechanical stresses under normotensive, prehypertensive and stage-1 hypertensive conditions using Fluid- Structure interaction modeling, and 2.) characterize the effect of hypertensive conditions on ventricular workload and coronary flow resistance. This study will provide insights on the mechano-etiology of CAVD in hypertensive patients as well as the ventricular functionality and coronary flow under hypertension.
Page Count
132
Department or Program
Department of Mechanical and Materials Engineering
Year Degree Awarded
2020
Copyright
Copyright 2020, all rights reserved. My ETD will be available under the "Fair Use" terms of copyright law.
ORCID ID
0000-0003-1477-0551
