Publication Date

2020

Document Type

Thesis

Committee Members

Philippe Sucosky, Ph.D. (Advisor);Zifeng Yang, Ph.D. (Committee Member); George P. Huang, Ph.D. (Committee Member)

Degree Name

Master of Science in Renewable and Clean Energy Engineering (MSRCE)

Abstract

Calcific aortic valve disease (CAVD), the most common valvular heart disorder, is associated with complications such as stroke, heart attack, aortic aneurysm, left ventricular hypertrophy, and ultimately death. While hypertension has been identified as a major risk factor for CAVD, the mechanisms by which it may promote calcification are still unknown. Given the sensitivity of valvular tissue to mechanical stress alterations, the hemodynamic abnormalities linked to hypertension may play a role in the development of CAVD. Further, the effects of hypertension on the left ventricular functionality and coronary flow resistance remain largely uninvestigated. Hence, the objectives of this thesis were 1.) to quantify computationally AV hemodynamics and regional leaflet mechanical stresses under normotensive, prehypertensive and stage-1 hypertensive conditions using Fluid- Structure interaction modeling, and 2.) characterize the effect of hypertensive conditions on ventricular workload and coronary flow resistance. This study will provide insights on the mechano-etiology of CAVD in hypertensive patients as well as the ventricular functionality and coronary flow under hypertension.

Page Count

132

Year Degree Awarded

2020

ORCID ID

0000-0003-1477-0551


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