Publication Date
2022
Document Type
Thesis
Committee Members
Adrian M. Corbett, Ph.D. (Advisor); Michael Mattot, Ph.D. (Committee Member); Christopher N. Wyatt, Ph.D. (Committee Member)
Degree Name
Master of Science (MS)
Abstract
Using forelimb asymmetry analysis along with Montoya Staircase methodology we tested how a fluoxetine simvastatin ascorbic acid drug cocktail would affect recovery from a demyelinating event in a rat model, with the hypothesis that if administered then it would help female recovery but hinder male recovery. It was found that a fluoxetine simvastatin and ascorbic acid drug cocktail did not significantly enhance recovery from a demyelination model injury in female rats, and that the same drug cocktail significantly slowed male rat recovery from the same type of injury. It was also apparent that the more effective methodology for investigating this model further would be the Montoya staircase. This was due to compensatory behavior masking the behavioral symptoms of white matter damage in forelimb asymmetry analysis.
Page Count
62
Department or Program
Department of Neuroscience, Cell Biology, and Physiology
Year Degree Awarded
2022
Copyright
Copyright 2022, some rights reserved. My ETD may be copied and distributed only for non-commercial purposes and may not be modified. All use must give me credit as the original author.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
