Publication Date
2022
Document Type
Thesis
Committee Members
Steven R. Higgins, Ph.D. (Advisor); David A. Dolson, Ph.D. (Committee Member); Rachel S. Aga, Ph.D. (Committee Member); Ioana E. Pavel, Ph.D. (Committee Member)
Degree Name
Master of Science (MS)
Abstract
Counterfeit pharmaceuticals are a serious threat to public safety worldwide. Adverse health effects including resistance to treatment and death have resulted from the consumption of such medicines. Aspirin, which is a non-steroidal anti-inflammatory drug, has been counterfeited in the past due to its increasing demand. Rapid and easy analytical methods are needed to detect these counterfeit medicines and put a halt to the growing number of such incidents. In this study, quantitative estimation of active pharmaceutical ingredient (API) content in different over-the-counter available aspirin tablets was done using titrimetry and UV- Visible spectrophotometry. Qualitative analysis was done using Raman spectroscopy. The quantitative results showed that the amount of API calculated in different brands using both methods was close to the amount of the API listed on the label. Student’s t-test indicated that there were no statistical differences in the results calculated from both methods. Raman spectra indicated the presence of impurities in some brands. The study demonstrated that titrimetry, UV-Visible spectrophotometry and Raman spectroscopy can be used to detect the amount of API in pharmaceutical formulations.
Page Count
93
Department or Program
Department of Chemistry
Year Degree Awarded
2022
Copyright
Copyright 2022, some rights reserved. My ETD may be copied and distributed only for non-commercial purposes and may not be modified. All use must give me credit as the original author.
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
