Publication Date


Document Type


Committee Members

Mark Rich, M.D., Ph.D. (Advisor); Andrew Ednie, Ph.D. (Committee Member); Kathrin Engisch, Ph.D. (Committee Member)

Degree Name

Master of Science (MS)


Hypokalemic Periodic Paralysis is an autosomal dominant disease of skeletal muscle in which patients experience episodes of weakness. There is currently no highly effective therapy. A mouse model has been created to study the disease to better understand the physiological changes leading to weakness and to develop novel treatments. However, the work done with the mouse model has used ever-changing protocols and the data produced have been insufficient to answer key questions and bring treatments closer to clinical trials. I evaluated factors of temperature, insulin, potassium concentrations, and length of protocol or exercise, to develop a protocol that reproducibly triggers weakness. I was able to successfully create a protocol that consistently produces paralysis (35°C, insulin, 4.75 to 1 mM K+, long protocol or exercise) to study the underlying pathophysiology and to evaluate novel therapy.

Page Count


Department or Program

Department of Neuroscience, Cell Biology, and Physiology

Year Degree Awarded