Publication Date
2009
Document Type
Thesis
Committee Members
Kathrin Engisch (Committee Member), Robert Putnam (Committee Member), Christopher Wyatt (Advisor)
Degree Name
Master of Science (MS)
Abstract
It has been previously shown that Carotid Body Type I cells have the ability to synthesize, package and release histamine in response to hypoxia, thereby contributing to the modulation of respiration within the rat. Here, isolated neonatal rat carotid body type I cells were used to identify the presynaptic effects of histamine and the specific receptor subtypes that modulate them. Although all four histamine receptor subtypes are expressed on the type I cells, and preliminary data showed promising results, further data proved that the activation of these receptors with histamine or selective agonists caused no rise in intracellular calcium ([Ca2+]i) and histamine did not augment calcium entry. Thus activation of histamine receptors on type I cells is unlikely to provide a presynaptic positive feedback mechanism during chemotransduction and any excitatory role attributed to the actions of histamine is likely to come from a postsynaptic effect on the carotid sinus nerve (CSN).
Page Count
114
Department or Program
Department of Neuroscience, Cell Biology & Physiology
Year Degree Awarded
2009
Copyright
Copyright 2009, all rights reserved. This open access ETD is published by Wright State University and OhioLINK.
