Publication Date
2014
Document Type
Thesis
Committee Members
Barbara Hull, Ph.D. (Advisor); Nancy Bigley, Ph.D. (Committee Member); John Paietta, Ph.D. (Committee Member)
Degree Name
Master of Science (MS)
Abstract
Five types of glucose transporters stimulate the transport of glucose from the bloodstream into cells such as muscle cells and adipocytes in response to insulin signaling or exercise. Skeletal muscle and adipose tissue are the main sites for glucose uptake and dispose in insulin action dependent pathway. In non-insulin stimulated condition, the GLUT4 storage vesicles stay away from the plasma membrane, so there is no GLUT4 translocation or GLUT4 mediated glucose uptake. However, in insulin stimulated state, insulin initiates insulin signaling cascade which results in rapid GLUT4 translocation and increased glucose uptake at the cell surface. Failure of the translocation of GLUT4 storage compartments into the plasma membrane in response to insulin stimulation or exercise may reduce the GLUT4 mediated glucose uptake and thus insulin resistance and type 2 DM development.
Page Count
40
Department or Program
Microbiology and Immunology
Year Degree Awarded
2014
Copyright
Copyright 2014, all rights reserved. My ETD will be available under the "Fair Use" terms of copyright law.
